INRICH: Interval-based Enrichment Analysis Tool for Genome Wide Association Studies
INRICH is a pathway analysis tool for genome wide association studies, designed for detecting enriched association signals of LD-independent genomic regions within biologically relevant gene sets. INRICH can
- Conduct pathway analysis on any type of genomic variation data, including but not limited to SNPs, CNVs, genes, as well as their combination.
- Run the positional clustering test of genomic intervals, which can be used to detect genomic regions with multiple independent, non-randomly clustered risk variants.
- Perform pathway analysis on multiple lists of associated genomic regions, which can be used for detecting functional gene sets with pleiotropic effects across related disorders or for a comparative study of pathway analysis across different datasets.
INRICH is a stand-alone C++ program, which supports both GUI and command line interfaces on Windows, Mac, and Linux.
INRICH is described in the reference below.
- Lee, PH, O’Dushlaine, C, Thomas, B, Purcell, S (2011). “INRICH: Interval-based enrichment analysis for genome-wide association studies" (In Press Bioinformatics).
INRICH has been used in the following work.
- Sklar P, Ripke S, Scott LJ, et al. (2011) “Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4” Nat Genet 43(10):977-83.